- The Stages of Liver Disease - American Liver Foundation
- Types of canine liver disease and causes of liver disease
- LIVER AND BILIARY DISEASE
Primary liver cancer is usually quite advanced prior to diagnoses and tends to metastasize to the rest of the body very early in the course of the disease.
The Stages of Liver Disease - American Liver Foundation
Fat metabolism is extremely complex due to the vast number of functions fat carries out in the body. The liver sits at the centre of those many functions.
Types of canine liver disease and causes of liver disease
Gamma Glutamyltransferase GGT: This enzyme is has it's highest concentration in the kidneys and pancreas, but it is also found in the liver and other organs. The major proportion of GGT in the serum seems to come from the liver. Elevations of GGT in disease seem to stem from new synthesis rather than leakage, therefore the changes seen due to disease are not spectacular. Large elevations of GGT are more commonly associated with pancreatitis and bile duct obstruction.
LIVER AND BILIARY DISEASE
Toxins include many common drugs, such as acetaminophen, ASA, anabolic steroids, chemotherapy drugs, some antibiotics, glucocorticoids, anaesthetics, parasite control drugs, and phenylbutazone. Some of the drug induced hepatitis is a predictable side effect of the drug, while other incidences of hepatitis are considered an unpredicted or abnormal side effect of the drug. This is difficult to diagnose unless there is a known exposure to the drug or toxin and the appropriate tests are taken. Biopsy will confirm liver destruction, inflammation, and fibrosis, but it will not single out the causative agent.
As part of its function, the liver makes bile, a fluid that contains among other substances, water, chemicals, and bile acids (made from stored cholesterol in the liver). Bile is stored in the gallbladder and when food enters the duodenum (the first part of the small intestine), bile is secreted into the duodenum, to aid in the digestion of food.
In patients with a severely reduced liver function we may see a true intolerance of ammonia and thus neurological signs after a heavy protein meal or we may see substantially reduced urea levels. This is a late sign in liver disease, only seen after 65 to 75 per cent of the liver function is gone.
Animals that receive a severe and blunt blow to the front of the abdomen can suffer from liver disease. The most common cause of this type of blow is being hit by a car. A liver lobe can be fractured and bleed into the abdomen, even leading to death. A more common occurrence is a bruise (contusion) that heals itself. Heatstroke, diaphragmatic hernia and liver lobe torsion can also cause liver problems.
Fever- a rectal temperature of greater than 658 degrees F could accompany liver disease when inflammation or infection is present
Alcohol abuse is the most common cause of liver disease in North America. Alcohol is directly toxic to liver cells and can cause liver inflammation, referred to as alcoholic hepatitis. In chronic alcohol abuse, fat accumulation occurs in liver cells affecting their ability to function. Cirrhosis
However, since there are a variety of liver diseases, the symptoms tend to be specific for that illness until late-stage liver disease and liver failure occurs.More pictures: «Liver disease stages death».